Recombinant Human Lamin B1 protein (ab114163)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P20700
    • 生物種Human
    • 配列MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKV RSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARER AKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALA TALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQS LTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMR EQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRI ESLSSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAE IRDQMQQQLNDYEQLLDVKLALDMEIS AYRKLLQGEEERLKLSPSPSS RVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEE IDVD GKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQ TVTIWAANAGVTASPPTDLIWKNQNSWGTGE DVKVILKNSQGEEVAQR STVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM
    • 分子量91 kDa including tags
    • 領域1 to 586

特性

Our Abpromise guarantee covers the use of ab114163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

    ELISA

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    ab114163 is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • ADLD
    • lamin B1
    • Lamin-B1
    • LMN
    • LMN2
    • LMNB
    • Lmnb1
    • LMNB1_HUMAN
    • MGC111419
    • OTTHUMP00000159218
    see all
  • 機能Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
  • 関連疾患Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.
  • 配列類似性Belongs to the intermediate filament family.
  • 翻訳後修飾B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
  • 細胞内局在Nucleus inner membrane.
  • Information by UniProt

Recombinant Human Lamin B1 protein 画像

  • 12.5% SDS-PAGE analysis of ab114163, stained with Coomassie Blue.

Recombinant Human Lamin B1 protein (ab114163) 使用論文

ab114163 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"