Recombinant Human l Afadin protein (ab91389)

製品の概要

  • 製品名Recombinant Human l Afadin protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 領域1 to 141

特性

Our Abpromise guarantee covers the use of ab91389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50mM Sodium chloride, 25mM HEPES, 1mM EDTA, pH 7.5

関連情報

  • 別名
    • AF6
    • AFAD_HUMAN
    • Afadin
    • ALL1-fused gene from chromosome 6 protein
    • Mllt4
    • Protein Af-6
    • Protein AF6
    see all
  • 機能Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
  • 関連疾患Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
  • 配列類似性Contains 1 dilute domain.
    Contains 1 FHA domain.
    Contains 1 PDZ (DHR) domain.
    Contains 2 Ras-associating domains.
  • ドメインThe PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus domain interacts with F-actin.
  • 細胞内局在Cell junction > adherens junction. Not found at cell-matrix AJs.
  • Information by UniProt

Recombinant Human l Afadin protein (ab91389) 使用論文

ab91389 has not yet been referenced specifically in any publications.

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