Recombinant Human Kisspeptin protein (ab78765)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG
    • 領域1 to 120

特性

Our Abpromise guarantee covers the use of ab78765 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab78765 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris, 1mM DTT, pH 8.0

関連情報

  • 別名
    • KISS 1
    • KiSS 1 metastasis suppressor
    • Kiss1
    • KISS1_HUMAN
    • Kisspeptin
    • Kisspeptin 1
    • Kisspeptin 10
    • Kisspeptin 13
    • Kisspeptin 14
    • Kisspeptin-1
    • Kisspeptin-10
    • Kisspeptin-54
    • Kisspeptin1
    • Malignant melanoma metastasis suppressor
    • Metastasis suppressor KiSS 1
    • Metastasis suppressor KiSS1
    • Metastin
    • MGC39258
    see all
  • 機能Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
  • 組織特異性Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
  • 配列類似性Belongs to the KISS1 family.
  • 翻訳後修飾Processed by MMP2 and MMP9.
  • 細胞内局在Secreted.
  • Information by UniProt

Recombinant Human Kisspeptin protein (ab78765) 使用論文

ab78765 has not yet been referenced specifically in any publications.

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