Recombinant Human Kir6.2 protein (ab114436)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLD EDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
    • 分子量
      36 kDa including tags
    • 領域
      301 to 390

特性

Our Abpromise guarantee covers the use of ab114436 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • ATP sensitive inward rectifier potassium channel 11
    • Beta cell inward rectifier subunit
    • BIR
    • HHF 2
    • HHF2
    • IKATP
    • Inward rectifier K(+) channel Kir6.2
    • Inwardly rectifying potassium channel KIR6.2
    • IRK 11
    • IRK11
    • KCNJ11
    • Kir 6.2
    • Kir6.2
    • MGC133230
    • PHHI
    • Potassium channel inwardly rectifing subfamily J member 11
    • Potassium channel, inwardly rectifying subfamily J member 11
    • Potassium inwardly rectifying channel J11
    • TNDM 3
    • TNDM3
    see all
  • 関連性
    ATP-sensitive potassium (K(ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K(ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.
  • 細胞内局在
    Cell Membrane; Multi-pass membrane protein

画像

  • ab114436 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

参考文献

ab114436 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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