Recombinant Human Kir4.1 protein (ab114456)

製品の概要

  • 製品名
    Recombinant Human Kir4.1 protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      DFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIA DFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVR ISNV
    • 分子量
      37 kDa including tags
    • 領域
      276 to 379

特性

Our Abpromise guarantee covers the use of ab114456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

    ELISA

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    ab114456 is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • ATP dependent inwardly rectifying potassium channel Kir4.1
    • ATP sensitive inward rectifier potassium channel 10
    • ATP-dependent inwardly rectifying potassium channel Kir4.1
    • ATP-sensitive inward rectifier potassium channel 10
    • BIRK10
    • Glial ATP dependent inwardly rectifying potassium channel KIR4.1
    • Inward rectifier K(+) channel Kir1.2
    • Inward rectifier K+ channel KIR1.2
    • Inwardly rectifying potassium channel Kir1.2
    • inwardly rectifying subfamily J member 10
    • KCJ10_HUMAN
    • KCNJ 10
    • Kcnj10
    • KCNJ13 PEN
    • KIR1.2
    • KIR4.1
    • Potassium channel
    • Potassium channel inwardly rectifying subfamily J member 10
    • Potassium inwardly rectifying channel subfamily J member 10
    • SESAME
    see all
  • 機能
    May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
  • 組織特異性
    Expressed in kidney (at protein level).
  • 関連疾患
    Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance
  • 配列類似性
    Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
  • 細胞内局在
    Membrane. Basolateral cell membrane. In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
  • Information by UniProt

画像

  • ab114456 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

参考文献

ab114456 has not yet been referenced specifically in any publications.

レビューと Q&A


Unfortunately, we cannot sell this product to you because of Dry Ice shipping restriction to Norway.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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