Recombinant Human Kir2.1 protein (ab114391)

製品の概要

  • 製品名Recombinant Human Kir2.1 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P63252
    • 生物種Human
    • 配列PVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYE NEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI
    • 分子量37 kDa including tags
    • 領域328 to 427

特性

Our Abpromise guarantee covers the use of ab114391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Western blot

    ELISA

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    ab114391 is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • Cardiac inward rectifier potassium channel
    • HHBIRK 1
    • HHBIRK1
    • HHIRK 1
    • HHIRK1
    • HIRK 1
    • hIRK1
    • Inward rectifier K
    • Inward rectifier K(+) channel Kir2.1
    • Inward rectifier potassium channel 2
    • inwardly rectifying subfamily J member 2
    • IRK 1
    • IRK-1
    • IRK1
    • IRK2_HUMAN
    • KCNJ2
    • KIR2.1
    • LQT 7
    • LQT7
    • Potassium channel
    • Potassium channel inwardly rectifying subfamily J member 2
    • Potassium inwardly rectifying channel J2
    • Potassium inwardly rectifying channel subfamily J member 2
    • SQT 3
    • SQT3
    see all
  • 機能Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
  • 組織特異性Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
  • 関連疾患Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7) [MIM:170390]; also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features.
    Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3) [MIM:609622]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves.
  • 配列類似性Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant Human Kir2.1 protein 画像

  • ab114391 analysed on a 12.5% SDS-PAGE Stained with Coomassie Blue.

Recombinant Human Kir2.1 protein (ab114391) 使用論文

ab114391 has not yet been referenced specifically in any publications.

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