Recombinant Human KDM5C / Jarid1C / SMCX protein (ab125608)

製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      118 kDa including tags
    • 領域
      1 to 671
    • タグ
      GST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

関連情報

  • 別名
    • DXS1272E
    • Histone demethylase JARID1C
    • JARID1C
    • JmjC domain containing protein SMCX
    • Jumonji AT rich interactive domain 1C
    • Jumonji, AT rich interactive domain 1C (RBP2 like)
    • Jumonji/ARID domain-containing protein 1C
    • KDM5C
    • KDM5C_HUMAN
    • Lysine (K) specific demethylase 5C
    • Lysine-specific demethylase 5C
    • MRX13
    • MRXJ
    • MRXSCJ
    • MRXSJ
    • Protein SmcX
    • Protein Xe169
    • rbp2 like protein
    • Selected cDNA on X
    • SMCX
    • Smcx homolog X chromosome
    • SmcX protein
    • Smcy homolog X linked
    • XE169
    • Xe169 protein
    see all
  • 機能
    Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.
  • 組織特異性
    Expressed in all tissues examined. Highest levels found in brain and skeletal muscle.
  • 関連疾患
    Defects in KDM5C are the cause of mental retardation syndromic X-linked JARID1C-related (MRXSJ) [MIM:300534]. MRXSJ is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRXSJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism.
  • 配列類似性
    Belongs to the JARID1 histone demethylase family.
    Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 2 PHD-type zinc fingers.
  • ドメイン
    The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.
    Both the JmjC domain and the JmjN domain are required for enzymatic activity.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

画像

  • SDS-PAGE analysis of ab125608.

参考文献

ab125608 has not yet been referenced specifically in any publications.

レビューと Q&A



Unfortunately, ab125608will show no activityas the storage buffer is not suitable for this purpose. In addition, it is a fragment, not the full length protein.

I hope this information is helpful to you. Please do not hesitate to cont...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録