製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      ELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDF HNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
    • 分子量
      37 kDa including tags
    • 領域
      292 to 391

特性

Our Abpromise guarantee covers the use of ab114590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • ATP regulated potassium channel ROM K
    • ATP sensitive inward rectifier potassium channel 1
    • ATP-regulated potassium channel ROM-K
    • ATP-sensitive inward rectifier potassium channel 1
    • Inward rectifier K(+) channel Kir1.1
    • inwardly rectifying K+ channel
    • inwardly rectifying subfamily J member 1
    • IRK1_HUMAN
    • KCNJ
    • KCNJ 1
    • Kcnj1
    • Kir 1.1
    • Kir1.1
    • OTTHUMP00000045938
    • Potassium channel
    • Potassium channel inwardly rectifying subfamily J member 1
    • potassium inwardly-rectifying channel J1
    • ROMK
    • ROMK 1
    • ROMK 2
    • ROMK1
    • ROMK2
    see all
  • 機能
    In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
  • 組織特異性
    In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.
  • 関連疾患
    Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) [MIM:241200]; also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
  • 配列類似性
    Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily.
  • 細胞内局在
    Membrane.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab114590 at approximately 36.63kDa stained with Coomassie Blue.

参考文献

ab114590 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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