Recombinant Human Kallikrein 7 protein (ab114437)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P49862
    • 生物種Human
    • 配列IDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHL GSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKK
    • 分子量37 kDa including tags
    • 領域31 to 130

特性

Our Abpromise guarantee covers the use of ab114437 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Chymotryptic stratum corneum
    • hK 7
    • hK7
    • hSCCE
    • Kallikrein 7 (chymotryptic stratum corneum)
    • Kallikrein related peptidase 7
    • Kallikrein-7
    • Kallikrein7
    • KLK 7
    • Klk7
    • KLK7_HUMAN
    • Protease serine 6
    • PRSS 6
    • PRSS6
    • SCCE
    • Serine protease 6
    • Signal protein
    • Stratum corneum chymotryptic enzyme
    see all
  • 機能May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-
    -Cys-7', '16-Tyr-
    -Leu-17', '25-Phe-
    -Tyr-26' and '26-Tyr-
    -Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
  • 組織特異性Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).
  • 配列類似性Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • 細胞内局在Secreted. In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
  • Information by UniProt

Recombinant Human Kallikrein 7 protein 画像

  • ab114437 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Kallikrein 7 protein (ab114437) 使用論文

ab114437 has not yet been referenced specifically in any publications.

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