Recombinant human JNK2 protein (ab119726)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号P45984
    • 生物種Human
    • 分子量70 kDa including tags
    • 領域1 to 424

特性

Our Abpromise guarantee covers the use of ab119726 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性ab119726 specific activity was determined to be 13 nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 25% Glycerol, 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.003% DTT, 0.002% PMSF, 0.003% EDTA

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • c Jun kinase 2
    • C Jun N terminal kinase 2
    • c-Jun N-terminal kinase 2
    • JNK 55
    • JNK-55
    • JNK2
    • JNK2 alpha
    • JNK2 beta
    • JNK2A
    • JNK2alpha
    • JNK2B
    • JNK2BETA
    • Jun kinase
    • MAP kinase 9
    • MAPK 9
    • Mapk9
    • Mitogen activated protein kinase 9
    • Mitogen-activated protein kinase 9
    • MK09_HUMAN
    • P54a
    • p54aSAPK
    • PRKM9
    • SAPK
    • SAPK alpha
    • SAPK1a
    • Stress activated protein kinase 1a
    • Stress-activated protein kinase JNK2
    see all
  • 機能Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.
    JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
  • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • ドメインThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • 翻訳後修飾Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme. Autophosphorylated in vitro.
  • Information by UniProt

Recombinant human JNK2 protein 画像

  • ab119726 specific activity was determined to be 13 nmol/min/mg.
  • SDS Page analysis of ab119726

Recombinant human JNK2 protein (ab119726) 使用論文

ab119726 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam with your questions pertaining to ab119726. I have been in contact with the laboratory about the questions that you have raised. The tag used in this preparation is GST. ab1198726 may be used in conjunction wi...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"