Recombinant Human Jarid2 protein (ab112313)

製品の概要

  • 製品名Recombinant Human Jarid2 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q92833
    • 生物種Human
    • 配列LQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLK LMYRYDEEQIISLVNQICGKVSGKNGSIENCLSKPTPKRGPRKRATVDVP
    • 分子量37 kDa
    • 領域1130 to 1229
    • タグGST tag N-Terminus

関連製品

特性

Our Abpromise guarantee covers the use of ab112313 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

関連情報

  • 別名
    • JARD2
    • JARD2_HUMAN
    • JARID2
    • JMJ
    • Jumonji AT rich interactive domain 2
    • Jumonji homolog
    • Jumonji like protein
    • Jumonji protein
    • Jumonji/ARID domain containing protein 2
    • Jumonji/ARID domain-containing protein 2
    • Protein Jumonji
    see all
  • 機能Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
  • 組織特異性During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
  • 配列類似性Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
  • ドメインThe ARID domain is required to target the PRC2 complex to its target genes.
    The GSGFP motif is required for the interaction with SUZ12.
  • 細胞内局在Nucleus. Colocalizes with the PRC2 complex on chromatin.
  • Information by UniProt

Recombinant Human Jarid2 protein 画像

  • ab112313 on a 12.5% SDS-PAGE stained with coomassie blue.

Recombinant Human Jarid2 protein (ab112313) 使用論文

ab112313 has not yet been referenced specifically in any publications.

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