製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      96 kDa
    • 領域
      1 to 596

特性

Our Abpromise guarantee covers the use of ab125546 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度
    > 80 % SDS-PAGE.
    Assessed by densitometry.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

関連情報

  • 別名
    • ASRT5
    • IL 1 receptor associated kinase M
    • IL-1 receptor-associated kinase M
    • IL1 receptor associated kinase M
    • Interleukin 1 receptor associated kinase 3
    • Interleukin 1 receptor associated kinase M
    • Interleukin-1 receptor-associated kinase 3
    • IRAK M
    • IRAK-3
    • IRAK-M
    • Irak3
    • IRAK3_HUMAN
    see all
  • 機能
    Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
  • 組織特異性
    Expressed predominantly in peripheral blood lymphocytes.
  • 関連疾患
    Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
  • 配列類似性
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt

画像

  • SDS-PAGE analysis of ab125546.

参考文献

ab125546 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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