製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Insect cells
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab79739 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Specific Activity: 18 pmol/min/µg.
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 400mM Sodium chloride, 3mM DTT, 25mM Tris HCl, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • IL-1 receptor-associated kinase 4
    • Interleukin 1 receptor associated kinase 4 mutant form 1
    • Interleukin-1 receptor-associated kinase 4
    • Interleukin1 receptor associated kinase 4
    • IPD1
    • IRAK 4
    • IRAK-4
    • IRAK4
    • IRAK4 mutated form 1
    • IRAK4_HUMAN
    • LOC 51135
    • NY REN 64
    • NY REN 64 antigen
    • NY-REN-64
    • REN64
    • Renal carcinoma antigen NY-REN-64
    see all
  • 機能Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.
  • 関連疾患Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.
    Defects in IRAK4 are the cause of IRAK4 deficiency (IRAK4D) [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt

Recombinant human IRAK4 protein 画像

  • 10% SDS-PAGE showing ab79739 at approximately 77.5kDa (4µg).
  • Kinase assay: Specific activity 18 pmol/min/µg.

Recombinant human IRAK4 protein (ab79739) 使用論文

ab79739 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"