Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Keratinocytes of epidermis and other stratified squamous epithelia.
Belongs to the involucrin family.
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
Cytoplasm. Constituent of the scaffolding of the cornified envelope.