製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P01579
    • 生物種Human
    • 分子量17 kDa
    • 領域24 to 166

特性

Our Abpromise guarantee covers the use of ab119140 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性> 2 x 107 units/mg 
  • アプリケーション

    Western blot

    ELISA

    Functional Studies

    SDS-PAGE

    HPLC

  • 精製度> 98 % SDS-PAGE.
    Purity: >98% by SDS PAGE and HPLC. Endotoxin Level: <0.1 ng/ug
  • 製品の状態Lyophilised
  • 備考 > 2 x 107 units/mg 
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    pH: 7.40
    Constituent: 0.16% Sodium phosphate

  • 再構成Reconstitute with 20ul distilled water.

関連情報

  • 別名
    • IFG
    • IFI
    • IFN gamma
    • IFN, immune
    • IFN-gamma
    • IFNG
    • IFNG_HUMAN
    • Immune interferon
    • Interferon gamma
    see all
  • 機能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
  • 組織特異性Released primarily from activated T lymphocytes.
  • 関連疾患In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
  • 配列類似性Belongs to the type II (or gamma) interferon family.
  • 翻訳後修飾Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • 細胞内局在Secreted.
  • Information by UniProt

Recombinant Human Interferon gamma protein (ab119140) 使用論文

This product has been referenced in:
  • Heinonen MT  et al. Tubulin- and actin-associating GIMAP4 is required for IFN-? secretion during Th cell differentiation. Immunol Cell Biol 93:158-66 (2015). Human . Read more (PubMed: 25287446) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"