Recombinant Human Integrin linked ILK protein (ab82815)

関連情報

• 別名
  • 59 kDa serine/threonine protein kinase
  • 59 kDa serine/threonine-protein kinase
  • DKFZp686F1765

  • Epididymis secretory protein Li 28
  • HEL S 28
  • ILK
  • ILK 1
  • ILK 2
  • ILK-1
  • ILK-2
  • ILK_HUMAN
  • ILK1
  • ILK2
  • Integrin linked Kinase
  • Integrin linked kinase 2
  • Integrin linked protein kinase
  • Integrin-linked protein kinase
  • p59
  • p59ILK

  see all
• 機能Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
• 組織特異性Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
• 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
  Contains 5 ANK repeats.
  Contains 1 protein kinase domain.
• ドメインA PH-like domain is involved in phosphatidylinositol phosphate binding.
• 翻訳後修飾Autophosphorylated on serine residues.
• 細胞内局在Cell junction > focal adhesion. Cell membrane.

• Target information above from: UniProt accession Q13418 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt