The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.3% Glutathione
ING 1 like tumor suppressor protein
ING1 like tumor suppressor protein
Inhibitor of growth 1 like
Inhibitor of growth 1 like protein
Inhibitor of growth 1-like protein
Inhibitor of growth family member 1 like
Inhibitor of growth family member 2
Inhibitor of growth protein 2
機能Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
組織特異性Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
配列類似性Belongs to the ING family. Contains 1 PHD-type zinc finger.
ドメインThe PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
細胞内局在Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.