製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q9H160
    • 生物種Human
    • 配列MLGQQQQQLYSSAALLTGERSRLLTCYVQDYLECVESLPHDMQRNVSVLR ELDNKYQETLKEIDDVYEKYKKEDDLNQKKRLQQLLQRALINSQELGDEK IQIVTQMLELVENRARQMELHSQCFQDPAESERASDKAKMDSSQPERSSR RPRRQRTSESRDLCHMANGIEDCDDQPPKEKKSKSAKKKKRSKAKQEREA SPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPK GKWYCPKCRGDNEKTMGKSTEKTKKDRRSR
    • 分子量57 kDa including tags
    • 領域1 to 280

特性

Our Abpromise guarantee covers the use of ab116739 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

    SDS-PAGE

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • ING 1 like tumor suppressor protein
    • ING 1L
    • ING 2
    • ING1 like tumor suppressor protein
    • ING1L
    • ING1Lp
    • ING2
    • ING2_HUMAN
    • Inhibitor of growth 1 like
    • Inhibitor of growth 1 like protein
    • Inhibitor of growth 1-like protein
    • Inhibitor of growth family member 1 like
    • Inhibitor of growth family member 2
    • Inhibitor of growth protein 2
    • p32
    • p33 ING2
    • p33ING2
    see all
  • 機能Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
  • 組織特異性Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
  • 配列類似性Belongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • ドメインThe PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
  • 細胞内局在Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
  • Information by UniProt

Recombinant Human ING2 protein 画像

  • 12.5% SDS-PAGE of ab116739 stained with Coomassie Blue.

Recombinant Human ING2 protein (ab116739) 使用論文

ab116739 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab116739.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"