製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      38 kDa including tags
    • 領域
      1 to 279
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度
    > 85 % Densitometry.
    Purity determined to be >85% by densitometry.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 0.002% PMSF, 0.81% Sodium phosphate, 0.0038% DTT, 25% Glycerol, 1.75% Sodium chloride

関連情報

  • 別名
    • 2610028J21Rik
    • AA407184
    • AI875420
    • Growth inhibitor ING 1
    • Growth inhibitor ING1
    • Growth inhibitory protein ING 1
    • Growth inhibitory protein ING1
    • Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds
    • ING 1
    • Ing1
    • ING1_HUMAN
    • Inhibitor of growth 1
    • Inhibitor of growth family member 1
    • Inhibitor of growth protein 1
    • mING1h
    • OTTHUMP00000018703
    • OTTHUMP00000018704
    • OTTHUMP00000018705
    • OTTHUMP00000018706
    • p24ING1c
    • p33
    • p33 ING1
    • p33ING1
    • p33ING1b
    • p33ING1c
    • p37Ing1b
    • p47
    • p47ING1a
    • Tumor suppressor ING 1
    • Tumor suppressor ING1
    see all
  • 機能
    Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
  • 組織特異性
    Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
  • 関連疾患
    Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.
  • 配列類似性
    Belongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

画像

  • SDS-PAGE analysis of ab125575.

参考文献

ab125575 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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