製品の概要

  • 製品名
    Recombinant Human IMPDH1 protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHH SSGLVPRGSH MADYLISGGT GYVPEDGLTA QQLFASADGL TYNDFLILPG FIDFIADEVD LTSALTRKIT LKTPLISSPM DTVTEADMAI AMALMGGIGF IHHNCTPEFQ ANEVRKVKKF EQGFITDPVV LSPSHTVGDV LEAKMRHGFS GIPITETGTM GSKLVGIVTS RDIDFLAEKD HTTLLSEVMT PRIELVVAPA GVTLKEANEI LQRSKKGKLP IVNDCDELVA IIARTDLKKN RDYPLASKDS QKQLLCGAAV GTREDDKYRL DLLTQAGVDV IVLDSSQGNS VYQIAMVHYI KQKYPHLQVI GGNVVTAAQA KNLIDAGVDG LRVGMGCGSI CITQEVMACG RPQGTAVYKV AEYARRFGVP IIADGGIQTV GHVVKALALG ASTVMMGSLL AATTEAPGEY FFSDGVRLKK YRGMGSLDAM EKSSSSQKRY FSEGDKVKIA QGVSGSIQDK GSIQKFVPYL IAGIQHGCQD IGARSLSVLR SMMYSGELKF EKRTMSAQIE GGVHGLHSYE KRLY
    • 分子量
      58 kDa including tags
    • 領域
      1 to 514
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab97410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF-TOF
  • 精製度
    > 95 % SDS-PAGE.
    ab97410 is purified using conventional chromatography techniques.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

関連情報

  • 別名
    • IMDH1_HUMAN
    • IMP (inosine monophosphate) dehydrogenase 1
    • IMP dehydrogenase 1
    • IMPD
    • IMPD 1
    • IMPD1
    • IMPDH 1
    • IMPDH I
    • IMPDH-I
    • Impdh1
    • Inosine 5' monophosphate dehydrogenase 1
    • Inosine monophosphate dehydrogenase 1
    • Inosine-5''-monophosphate dehydrogenase 1
    • LCA11
    • RP10
    • sWSS2608
    see all
  • 機能
    Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • 組織特異性
    IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • パスウェイ
    Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
  • 関連疾患
    Defects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.
  • 配列類似性
    Belongs to the IMPDH/GMPR family.
    Contains 2 CBS domains.
  • Information by UniProt

画像

  • 15% SDS-PAGE showing ab97410 at approximately 57.5kDa (3µg).

参考文献

ab97410 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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