製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human
    • 領域
      20 to 357

特性

Our Abpromise guarantee covers the use of ab53370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 20mM Tris, pH 8

関連情報

  • 別名
    • CD 126
    • CD126
    • CD126 antigen
    • gp80
    • IL 6R
    • IL 6R 1
    • IL 6R alpha
    • IL-6 receptor alpha chain
    • IL-6 receptor subunit alpha
    • IL-6R 1
    • IL-6R subunit alpha
    • IL-6R-alpha
    • IL-6RA
    • IL6Q
    • Il6r
    • IL6RA
    • IL6RA_HUMAN
    • IL6RQ
    • Interleukin 6 receptor
    • interleukin 6 receptor, alpha
    • Interleukin-6 receptor subunit alpha
    • Membrane glycoprotein 80
    • MGC30256
    see all
  • 機能
    Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
    Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
  • 組織特異性
    Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
  • 配列類似性
    Belongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 1 fibronectin type-III domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • ドメイン
    The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • 翻訳後修飾
    A short soluble form may also be released from the membrane by proteolysis.
  • 細胞内局在
    Secreted and Basolateral cell membrane.
  • Information by UniProt

画像

  • SDS-PAGE analysis of ab53370

参考文献

ab53370 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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