Recombinant human IL6 protein (ab9627)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P05231
    • 生物種Human
    • 配列PVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMC ESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEY LQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTK LQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
    • 分子量21 kDa
    • 領域1 to 184

関連製品

特性

Our Abpromise guarantee covers the use of ab9627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性

    Determined by its ability to stimulate the proliferation of the IL-6 dependent mouse 7TD1 cells.The expected ED50 is ≤0.1 ng/mL, corresponding to a specific activity of ≥ 1 x 107 units/mg.

  • アプリケーション

    SDS-PAGE

    Functional Studies

    Neutralising

  • エンドトキシン・レベル< 0.100 Eu/µg
  • 精製度> 98 % SDS-PAGE.
    Sterile filtered. Greater than 98% pure by SDS-PAGE and HPLC analyses.
  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成Centrifuge the vial prior to opening. Reconstitute in 5-10 mM Acetic Acid to a concentration of 0.1-0.5 mg/ml

関連情報

  • 別名
    • Interleukin BSF 2
    • B cell differentiation factor
    • B cell stimulatory factor 2
    • B-cell stimulatory factor 2
    • BSF 2
    • BSF-2
    • BSF2
    • CDF
    • CTL differentiation factor
    • Hepatocyte stimulatory factor
    • HGF
    • HSF
    • Hybridoma growth factor
    • Hybridoma growth factor Interferon beta-2
    • IFN-beta-2
    • IFNB2
    • IL 6
    • IL-6
    • IL6
    • IL6_HUMAN
    • Interferon beta 2
    • Interferon beta-2
    • Interleukin 6
    • Interleukin 6 (interferon beta 2)
    • Interleukin BSF 2
    • Interleukin-6
    see all
  • 機能Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
  • 関連疾患Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
    Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
  • 配列類似性Belongs to the IL-6 superfamily.
  • 翻訳後修飾N- and O-glycosylated.
  • 細胞内局在Secreted.
  • Information by UniProt

Recombinant human IL6 protein (ab9627) 使用論文

ab9627 has not yet been referenced specifically in any publications.

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Dieses Protein muss in 5-10mM Essigsäure (Acetic acid) aufgenommen werden damit eine volle Solubilisierung gewährleistet werden kann. Wir empfehlen eine Endkonzentration des Proteins von 0.1-0.5 mg/ml.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"