Recombinant human IL1RA protein (ab119745)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P18510
    • 生物種Human
    • 配列The sequence of the first five N-terminal amino acids was determined and was found to be Met-Arg-Pro-Ser-Gly.
    • 分子量17 kDa
    • 領域26 to 177

特性

Our Abpromise guarantee covers the use of ab119745 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The ED50 as determined by the dose-dependent inhibition of IL1 stimulation of D10S cells was found to be 0.5 ng/ml.
  • アプリケーション

    SDS-PAGE

    HPLC

    Functional Studies

  • 精製度> 95 % SDS-PAGE.
    Purified by proprietary chromatographic techniques the purity was determined to be > 98 % by SDS-PAGE and RP-HPLC.
  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成Reconstitute in sterile ddH2O to a concentration >= 100 µg/ml.

関連情報

  • 別名
    • DIRA
    • ICIL 1RA
    • ICIL-1RA
    • ICIL1RA
    • IL-1ra
    • IL-1ra3
    • IL-1RN
    • IL1 inhibitor
    • IL1F3
    • IL1RA
    • IL1RA_HUMAN
    • IL1RN
    • IL1RN (IL1F3)
    • Interleukin 1 receptor antagonist
    • Interleukin-1 receptor antagonist protein
    • Intracellular IL 1 receptor antagonist type II
    • Intracellular interleukin 1 receptor antagonist (icIL 1ra)
    • IRAP
    • MGC10430
    • MVCD4
    • Type II interleukin 1 receptor antagonist
    see all
  • 機能Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
  • 組織特異性The intracellular form of IL1RN is predominantly expressed in epithelial cells.
  • 関連疾患Microvascular complications of diabetes 4
    Interleukin 1 receptor antagonist deficiency
  • 細胞内局在Cytoplasm and Secreted.
  • Information by UniProt

Recombinant human IL1RA protein (ab119745) 使用論文

ab119745 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. We generally ship these proteins overnight on an ice pack at 4C. The lyophilized protein ab119745 should be stable for longer shipment at ambient temperature, but the liquid protein may not be. I am currently checking with ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"