製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    HEK 293 cells
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      Theoretical sequence: GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKR SSDYYNRSTSPWNLHRNEDPE RYPSVIWEAKCRHLGCINADGNVDYHM NSVPIQQEILVLRREPPHCPNSFRLEKILVSVGC TCVTPIVHHVA

特性

Our Abpromise guarantee covers the use of ab83769 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The activity of IL17 is measured by its ability to induce IL6 production in NHDF cells. The ED50 is typically between 0.5 and 1.5 ng/ml.
  • アプリケーション

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Trehalose, 1% Human serum albumin

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成
    It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. Following reconstitution short-term storage at 4°C and longer-term storage of aliquots at -18 to -20°C is recommended. Repeated freeze thawing is not recommended.

関連情報

  • 別名
    • CTLA 8
    • CTLA-8
    • CTLA8
    • Cytotoxic T lymphocyte associated antigen 8
    • Cytotoxic T lymphocyte associated protein 8
    • Cytotoxic T lymphocyte associated serine esterase 8
    • Cytotoxic T-lymphocyte-associated antigen 8
    • IL 17A
    • IL-17
    • IL-17A
    • IL17
    • IL17_HUMAN
    • Il17a
    • Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8)
    • Interleukin 17A
    • Interleukin-17A
    • Interleukin17
    • Interleukin17A
    • OTTHUMP00000016597
    • OTTMUSP00000046003
    see all
  • 機能
    Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
  • 組織特異性
    Restricted to activated memory T-cells.
  • 配列類似性
    Belongs to the IL-17 family.
  • 翻訳後修飾
    Found both in glycosylated and nonglycosylated forms.
  • 細胞内局在
    Secreted.
  • Information by UniProt

参考文献

ab83769 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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