製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYN RSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQE ILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVAMRKIPKVGHTFFQ KPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNR YPSEVVQAQCRNLGCINAQGKEDISM-NSVPIQQETLVVRRKHQGCSVSF QLEKVLVTVGCTCVTPVIHHVQ
    • 分子量
      31 kDa
    • 領域
      20 to 155

特性

Our Abpromise guarantee covers the use of ab119440 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The ED50 of recombinant Human IL17, as determined by the production of IL6 by NIH3T3 cells, was typically found to be 3-15 ng/ml.
  • アプリケーション

    SDS-PAGE

    HPLC

    Functional Studies

  • 精製度
    > 95 % SDS-PAGE.
    ab119440 is purified by proprietary chromatographic techniques. Purity is > 98 % by SDS-PAGE and HPLC.
  • 製品の状態
    Lyophilised
  • 備考
    Endotoxin level is <0.1 ng/µg.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20ºC.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成
    Centrifuge the vial prior to opening. Reconstitute with sterile water to a concentration of 0.1 mg/ml, the solution can then be diluted into other aqueous buffers. For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA).

関連情報

  • 別名
    • CTLA 8
    • CTLA-8
    • CTLA8
    • Cytotoxic T lymphocyte associated antigen 8
    • Cytotoxic T lymphocyte associated protein 8
    • Cytotoxic T lymphocyte associated serine esterase 8
    • Cytotoxic T-lymphocyte-associated antigen 8
    • IL 17A
    • IL-17
    • IL-17A
    • IL17
    • IL17_HUMAN
    • Il17a
    • Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8)
    • Interleukin 17A
    • Interleukin-17A
    • Interleukin17
    • Interleukin17A
    • OTTHUMP00000016597
    • OTTMUSP00000046003
    see all
  • 機能
    Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
  • 組織特異性
    Restricted to activated memory T-cells.
  • 配列類似性
    Belongs to the IL-17 family.
  • 翻訳後修飾
    Found both in glycosylated and nonglycosylated forms.
  • 細胞内局在
    Secreted.
  • Information by UniProt

参考文献

ab119440 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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