Recombinant human IGF1 Receptor beta subunit protein (ab80349)

製品の概要

  • 製品名Recombinant human IGF1 Receptor beta subunit protein
  • タンパク質長Protein fragment

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Insect cells
  • アミノ酸配列
    • 生物種Human
    • 領域930 to 1337

特性

Our Abpromise guarantee covers the use of ab80349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Specific activity: ~100 nmol/min/mg at 25°C using poly(Glu:Tyr)4:1 substrate. Reaction conditions are 50 mM Tris, pH 7.5, 5 mM MgCl2, 5 mM MnCl2, 1 mM DTT, 250 µM ATP. The kinase concentration was 0.5-1 µM and poly-L-lysine was added in equimolar amounts to the kinase.
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50mM Tris, 1mM DTT, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • CD221
    • CD221 antigen
    • EC 2.7.10.1
    • IGF I receptor
    • IGF-I receptor
    • Igf1r
    • IGF1R_HUMAN
    • IGFIR
    • Insulin like growth factor 1 receptor alpha chain
    • Insulin like growth factor 1 receptor beta chain
    • Insulin like growth factor I receptor
    • Insulin-like growth factor 1 receptor beta chain
    • Insulin-like growth factor I receptor
    • JTK13
    • MGC142170
    • MGC142172
    • MGC18216
    • Soluble IGF1R variant 1
    • Soluble IGF1R variant 2
    see all
  • 機能This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
  • 組織特異性Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues.
  • 関連疾患Defects in IGF1R are a cause of insulin-like growth factor 1 resistance (IGF1RES) [MIM:270450]. It is a disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 3 fibronectin type-III domains.
    Contains 1 protein kinase domain.
  • 翻訳後修飾The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I).
    Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant human IGF1 Receptor beta subunit protein (ab80349) 使用論文

ab80349 has not yet been referenced specifically in any publications.

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This productdoesn’t contain p-IGF-1R beta and doesn’t need to phosphorylate it in vitro for the enzyme activity.


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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"