Recombinant Human HYAL1 protein (ab112304)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q12794-3
    • 生物種Human
    • 配列MAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQL GWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLP VLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKES CQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLL NPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERK SMW
    • 分子量54 kDa including tags
    • 領域1 to 253
    • タグGST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab112304 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性useful for Antibody Production and Protein Array
  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 備考Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

関連情報

  • 別名
    • HYAL 1
    • Hyal-1
    • HYAL1
    • HYAL1_HUMAN
    • Hyaluronidase 1
    • Hyaluronidase-1
    • Hyaluronoglucosaminidase 1
    • Hyaluronoglucosaminidase-1
    • Hyaluronoglucosaminidase1
    • LUCA 1
    • LUCA-1
    • LUCA1
    • Lung carcinoma protein 1
    • MGC45987
    • NAT6
    • Plasma hyaluronidase
    • Tumor suppressor LUCA 1
    see all
  • 機能May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
  • 組織特異性Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
  • 関連疾患Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9) [MIM:601492]; also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.
  • 配列類似性Belongs to the glycosyl hydrolase 56 family.
    Contains 1 EGF-like domain.
  • 細胞内局在Secreted. Lysosome.
  • Information by UniProt

Recombinant Human HYAL1 protein 画像

  • ab112304 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue

Recombinant Human HYAL1 protein (ab112304) 使用論文

ab112304 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"