Recombinant Human Huntingtin Interacting Protein HIP1 (ab116725)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      DSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIK RQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPP TLQEVVTEKE
    • 分子量
      38 kDa including tags
    • 領域
      928 to 1037

特性

Our Abpromise guarantee covers the use of ab116725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

    SDS-PAGE

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • 2610109B09Rik
    • A930014B11Rik
    • E130315I21Rik
    • HIP 1
    • HIP I
    • HIP-1
    • HIP-I
    • hip1
    • HIP1/PDGFRB fusion gene
    • HIP1/PDGFRB fusion gene, included
    • HIP1_HUMAN
    • HIPI
    • Huntingtin interacting protein 1
    • Huntingtin-interacting protein 1
    • Huntingtin-interacting protein I
    • ILWEQ
    • KIAA4113
    • MGC126506
    • MGC27616
    • mKIAA4113
    see all
  • 機能
    Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
  • 組織特異性
    Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
  • 関連疾患
    Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.
  • 配列類似性
    Belongs to the SLA2 family.
    Contains 1 ENTH (epsin N-terminal homology) domain.
    Contains 1 I/LWEQ domain.
  • ドメイン
    The pseudo DED region (pDED) mediates the interaction with IFT57.
    Binds F-actin via the talin-like I/LWEQ domain.
  • 細胞内局在
    Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab116725 at approximately 37.73kDa.
    Stained with Coomassie Blue.

参考文献

ab116725 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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