製品の概要

  • 製品名
    Recombinant Human HuD protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      VLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGY RLGDRVLQVSFKTNKAHKS
    • 分子量
      33 kDa including tags
    • 領域
      312 to 380

関連製品

特性

Our Abpromise guarantee covers the use of ab114734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • ELAV (embryonic lethal abnormal vision Drosophila) like 4
    • ELAV L4
    • ELAV like 4
    • ELAV like protein 4
    • ELAV-like protein 4
    • ELAV4_HUMAN
    • Elavl4
    • Embryonic lethal abnormal vision Drosophila homolog of like 4
    • Hu antigen D
    • Hu-antigen D
    • HuD
    • Paraneoplastic encephalomyelitis antigen HuD
    • PNEM
    see all
  • 機能
    May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.
  • 組織特異性
    Brain.
  • 配列類似性
    Belongs to the RRM elav family.
    Contains 3 RRM (RNA recognition motif) domains.
  • 翻訳後修飾
    Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth.
  • Information by UniProt

Recombinant Human HuD protein 画像

  • 12.5% SDS-PAGE showing ab114734 at approximately 33.22kDa.
    Stained with Coomassie Blue.

Recombinant Human HuD protein (ab114734) 使用論文

ab114734 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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