製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P10809
    • 生物種Human
    • 分子量60 kDa
    • 領域1 to 573

特性

Our Abpromise guarantee covers the use of ab113192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性ATPase activity assay (positive)but there is not quantification of activity
  • アプリケーション

    Western blot

    Peptide Array

    SDS-PAGE

    Functional Studies

    ELISA

  • エンドトキシン・レベル> 500.000 Eu/mg
  • 精製度> 90 % SDS-PAGE.
    ab113192 is purified by multi-step chromatography.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Constituent: 100% PBS
    Note: Dulbecco's PBS.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 60 kDa chaperonin
    • 60 kDa heat shock protein, mitochondrial
    • CH60_HUMAN
    • Chaperonin 60
    • Chaperonin, 60-KD
    • CPN60
    • fa04a05
    • GROEL
    • heat shock 60kDa protein 1 (chaperonin)
    • Heat shock protein 1 (chaperonin)
    • Heat shock protein 60
    • Heat shock protein 65
    • heat shock protein family D (Hsp60) member 1
    • HLD4
    • Hsp 60
    • HSP 65
    • HSP-60
    • HSP60
    • HSP65
    • HSPD1
    • HuCHA60
    • Mitochondrial matrix protein P1
    • P60 lymphocyte protein
    • short heat shock protein 60 Hsp60s1
    • SPG13
    see all
  • 機能Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
  • 関連疾患Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13) [MIM:605280]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
    Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4) [MIM:612233]; also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.
  • 配列類似性Belongs to the chaperonin (HSP60) family.
  • 細胞内局在Mitochondrion matrix.
  • Information by UniProt

Recombinant human Hsp60 protein 画像

  • SDS-PAGE showing ab113192 at approximately 60kDa (1µg).
  • All lanes : anti-Hsp60 mAb at 1 µg/ml

    Lane 1 : Recombinant human Hsp60 protein (ab113192)
    Lane 2 : GroEL protein

    Lysates/proteins at 0.1 µg per lane.

Recombinant human Hsp60 protein (ab113192) 使用論文

ab113192 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"