Recombinant Human HRG beta 1 protein (ab55742)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQ NYVM ASFYKHLGIE FMEAE

特性

Our Abpromise guarantee covers the use of ab55742 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 精製度
    > 98 % SDS-PAGE.
    purification checked by SDS Page and HPLC.
  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Endotoxin level: < 0.1 ng per µg of HRG beta-1

  • 再構成
    Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

関連情報

  • 別名
    • Acetylcholine receptor inducing activity
    • ARIA
    • Breast cancer cell differentiation factor p45
    • GGF
    • GGF2
    • glial growth factor
    • Heregulin
    • Heregulin beta1
    • heregulin, alpha (45kD, ERBB2 p185 activator)
    • HGL
    • HRG
    • HRG beta 1A
    • HRG1
    • HRGA
    • NDF
    • neu differentiation factor
    • Neuregulin 1
    • NRG1
    • sensory and motor neuron derived factor
    • SMDF
    see all
  • 関連性
    HRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. HRG1-ß1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-ß1 biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF).
  • 細胞内局在
    Secreted

参考文献

ab55742 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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