製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P00492
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MATRSPGVVI SDDEPGYDLD LFCIPNHYAE DLERVFIPHG LIMDRTERLA RDVMKEMGGH HIVALCVLKG GYKFFADLLD YIKALNRNSD RSIPMTVDFI RLKSYCNDQS TGDIKVIGGD DLSTLTGKNV LIVEDIIDTG KTMQTLLSLV RQYNPKMVKV ASLLVKRTPR SVGYKPDFVG FEIPDKFVVG YALDYNEYFR DLNHVCVISE TGKAKYKA
    • 分子量27 kDa
    • 領域1 to 218
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab97411 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

    Western blot

  • 質量分析
    MALDI-TOF-TOF
  • 精製度> 95 % SDS-PAGE.
    ab97411 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, pH 8.0

関連情報

  • 別名
    • HGPRT
    • HGPRTase
    • HPRT 1
    • HPRT_HUMAN
    • HPRT1
    • Hypoxanthine guanine phosphoribosyltransferase
    • Hypoxanthine phosphoribosyltransferase 1
    • Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome)
    • Hypoxanthine-guanine phosphoribosyltransferase
    see all
  • 機能Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
  • パスウェイPurine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
  • 関連疾患Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS) [MIM:300322]. LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation.
    Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT) [MIM:300323]; also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia.
  • 配列類似性Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Recombinant Human HPRT protein 画像

  • 15% SDS-PAGE showing ab97411 at approximately 26.7kDa (3µg).

Recombinant Human HPRT protein (ab97411) 使用論文

ab97411 has not yet been referenced specifically in any publications.

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