Recombinant Human HP1 alpha protein (ab124602)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P45973
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MGSHMGKKTK RTADSSSSED EEEYVVEKVL DRRVVKGQVE YLLKWKGFSE EHNTWEPEKN LDCPELISEF MKKYKKMKEG ENNKPREKSE SNKRKSNFSN SADDIKSKKK REQSNDIARG FERGLEPEKI IGATDSCGDL MFLMKWKDTD EADLVLAKEA NVKCPQIVIA FYEERLTWHA YPEDAENKEK ETAKS
    • 分子量25 kDa including tags
    • 領域1 to 191
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab124602 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 90 % SDS-PAGE.
    ab124602 is purified by using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 30% Glycerol, 0.58% Sodium chloride

関連情報

  • 別名
    • Antigen p25
    • CBX5
    • CBX5_HUMAN
    • CG8409
    • Chromobox 5
    • Chromobox homolog 5
    • Chromobox homolog 5 (HP1 alpha homolog, Drosophila)
    • Chromobox protein homolog 5
    • Epididymis luminal protein 25
    • HEL25
    • Heterochromatin protein 1
    • Heterochromatin protein 1 alpha
    • Heterochromatin protein 1 homolog alpha
    • HP1
    • HP1 alpha
    • HP1 alpha homolog
    • HP1A
    • HP1Hs alpha
    • Su(var)205
    see all
  • 機能Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
  • 配列類似性Contains 2 chromo domains.
  • 翻訳後修飾Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
    Ubiquitinated.
  • 細胞内局在Nucleus. Chromosome. Chromosome > centromere. Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
  • Information by UniProt

Recombinant Human HP1 alpha protein 画像

  • 15% SDS-PAGE showing ab124602 (3 µg).

Recombinant Human HP1 alpha protein (ab124602) 使用論文

ab124602 has not yet been referenced specifically in any publications.

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