Recombinant Human hnRNP C1 + C2 protein (ab125177)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P07910
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSSFD LDYDFQRDYY DRMYSYPARV PPPPPIARAV VPSKRQRVSG NTSRRGKSGF NSKSGQRGSS KSGKLKGDDL QAIKKELTQI KQKVDSLLEN LEKIEKEQSK QAVEMKNDKS EEEQSSSSVK KDETNVKMES EGGADDSAEE GDLLDDDDNE DRGDDQLELI KDDEKEAEEG EDDRDSANGE DDS
    • 分子量35 kDa including tags
    • 領域1 to 293
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125177 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 85 % SDS-PAGE.
    ab125177 is purified by proprietary chromatographic techniques. Purity is greater than 85.0% as determined by SDS-PAGE.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.08% DTT, 0.32% Tris HCl, 30% Glycerol, 1.17% Sodium chloride

関連情報

  • 別名
    • C1
    • C2
    • Heterogeneous nuclear ribonucleoprotein C
    • Heterogeneous nuclear ribonucleoprotein C (C1/C2)
    • Heterogeneous nuclear ribonucleoproteins C1/C2
    • HNRNP
    • hnRNP C1 / hnRNP C2
    • hnRNP C1/C2
    • Hnrnpc
    • HNRPC
    • HNRPC_HUMAN
    • MGC104306
    • MGC105117
    • MGC117353
    • MGC131677
    • Nuclear ribonucleoprotein particle C1 protein
    • Nuclear ribonucleoprotein particle C2 protein
    • SNRPC
    see all
  • 機能Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).
  • 配列類似性Belongs to the RRM HNRPC family. RALY subfamily.
    Contains 1 RRM (RNA recognition motif) domain.
  • 翻訳後修飾Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
    Sumoylated. Sumoylation reduces affinity for mRNA.
  • 細胞内局在Nucleus. Component of ribonucleosomes.
  • Information by UniProt

Recombinant Human hnRNP C1 + C2 protein (ab125177) 使用論文

ab125177 has not yet been referenced specifically in any publications.

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