Recombinant Human HNF1 beta protein (ab116782)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      VRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDA CSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAE CLQRG
    • 分子量
      37 kDa including tags
    • 領域
      173 to 277

関連製品

特性

Our Abpromise guarantee covers the use of ab116782 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

    ELISA

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • FJHN
    • Hepatocyte nuclear factor 1 beta
    • Hepatocyte nuclear factor 1-beta
    • HNF 1B
    • HNF 2
    • HNF-1-beta
    • HNF-1B
    • HNF1 beta
    • HNF1 homeobox B
    • HNF1B
    • HNF1B_HUMAN
    • HNF1beta
    • HNF2
    • Homeoprotein LF B3
    • Homeoprotein LFB3
    • HPC11
    • LF B3
    • LFB3
    • MODY 5
    • MODY5
    • TCF 2
    • TCF 2 protein
    • TCF-2
    • TCF2
    • TCF2 protein
    • Transcription factor 2
    • Transcription factor 2 hepatic
    • Variant hepatic nuclear factor
    • Variant hepatic nuclear factor 1
    • VHNF 1
    • vHNF1
    see all
  • 機能
    Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
  • 関連疾患
    Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD) [MIM:137920]; also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy.
    Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.
    Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11) [MIM:611955]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • 配列類似性
    Belongs to the HNF1 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE showing ab116782 at approximately 37.29kDa.
    Stained with Coomassie Blue.

参考文献

ab116782 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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