Recombinant Human HMGA1a / HMGA1b protein (ab109927)

製品の概要

  • 製品名Recombinant Human HMGA1a / HMGA1b protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P17096
    • 生物種Human
    • 配列MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSE VPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQ ESSEEEQLEH HHHHH
    • 分子量13 kDa including tags
    • 領域1 to 107
    • タグHis tag C-Terminus

特性

Our Abpromise guarantee covers the use of ab109927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 90 % SDS-PAGE.
    ab109927 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 50% Glycerol, 0.02% DTT, 0.32% Tris HCl, 1.12% Sodium chloride

関連情報

  • 別名
    • High mobility group AT hook 1
    • High mobility group AT-hook protein 1
    • High mobility group protein A1
    • High mobility group protein HMG-I/HMG-Y
    • High mobility group protein R
    • HMG-I(Y)
    • HMGA 1a
    • HMGA 1b
    • HMGA1
    • HMGA1_HUMAN
    • HMGI
    • HMGI/Y
    • HMGR
    • HMGY
    see all
  • 機能HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
  • 関連疾患Note=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51L1.
  • 配列類似性Belongs to the HMGA family.
    Contains 3 A.T hook DNA-binding domains.
  • 翻訳後修飾Constitutively phosphorylated on two or three sites. Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoform HMG-Y can be phosphorylated by HIPK2.
    HMG-Y is not methylated.
    Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
  • 細胞内局在Nucleus. Chromosome.
  • Information by UniProt

Recombinant Human HMGA1a / HMGA1b protein 画像

  • 15% SDS-PAGE showing ab109927 at approximately 12.7 kDa (3µg).

Recombinant Human HMGA1a / HMGA1b protein (ab109927) 使用論文

ab109927 has not yet been referenced specifically in any publications.

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