製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P05114
    • 生物種Human
    • 配列MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD LEHHHHHH
    • 分子量12 kDa including tags
    • 領域1 to 100
    • タグHis tag C-Terminus
    • 配列の追加情報HMGN1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids (1-100 a.a.) and having a molecular mass of 11.7 kDa.

特性

Our Abpromise guarantee covers the use of ab117159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    ab117159 was purified by standard chromatography and filter sterilized.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 0.58% Sodium chloride, 0.003% PMSF, 20% Glycerol

関連情報

  • 別名
    • FLJ27265
    • FLJ31471
    • High mobility group (nonhistone chromosomal) protein 14
    • High mobility group nucleosome binding 1
    • High mobility group nucleosome binding domain 1
    • High mobility group nucleosome binding domain containing protein 1
    • High mobility group nucleosome-binding domain-containing protein 1
    • High mobility group protein 14
    • HMG 14
    • HMG14
    • HMGN 1
    • HMGN1
    • HMGN1_HUMAN
    • MGC104230
    • MGC117425
    • Non-histone chromosomal protein HMG-14
    • Nonhistone chromosomal protein HMG 14
    • Nonhistone chromosomal protein HMG14
    see all
  • 機能Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.
  • 配列類似性Belongs to the HMGN family.
  • 翻訳後修飾Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
  • 細胞内局在Nucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
  • Information by UniProt

Recombinant Human HMG14 protein (ab117159) 使用論文

ab117159 has not yet been referenced specifically in any publications.

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