Recombinant Human Histamine H2 Receptor + GsaS fusion protein (ab90399)

製品の概要

  • 製品名Recombinant Human Histamine H2 Receptor + GsaS fusion protein
  • タンパク質長Full length protein
  • 製品の詳細
    Recombinant Human Histamine H2 Receptor + GsαS fusion protein

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human
    • 分子量85 kDa
    • 配列の追加情報Tagged at the N terminus of the Histamine H2 Receptor with a DDDDK tag. The C terminus of the Histamine H2 Receptor is linked to the N terminus of the Gs alpha S with a His tag.

特性

Our Abpromise guarantee covers the use of ab90399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

関連情報

  • 別名
    • Adenylate cyclase stimulating G alpha protein
    • AHO
    • C20orf45
    • dJ309F20.1.1
    • dJ806M20.3.3
    • Extra large alphas protein
    • Gastric receptor 1
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • Gs alpha subunit
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms short
    • Guanine nucleotide regulatory protein
    • H2R
    • HGNC:5183
    • Histamine H2 receptor
    • Histamine receptor H2
    • Neuroendocrine secretory protein
    • PHP1A
    • PHP1B
    • POH
    • Secretogranin VI
    • XLalphas
    see all
  • 関連性The H2 subclass of histamine receptors mediates gastric acid secretion. It also appears to regulate gastrointestinal motility and intestinal secretion. HRH2 has a possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined.
  • 細胞内局在Histamine H2 Receptor: Membrane; multi pass membrane protein.

Recombinant Human Histamine H2 Receptor + GsaS fusion protein (ab90399) 使用論文

ab90399 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab90399.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"