製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab85601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The Specific activity of ab85601 was determined to be 48 nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

  • 製品の状態Liquid
  • 備考

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 150mM Imidazole
    Constituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.2mM DTT, 0.1mM PMSF, pH 7.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Androgen receptor interacting nuclear protein kinase
    • Androgen receptor-interacting nuclear protein kinase
    • ANPK
    • DYRK6
    • Fas interacting serine/threonine protein kinase
    • Fas-interacting serine/threonine-protein kinase
    • FIST
    • FIST3
    • Hipk3
    • HIPK3_HUMAN
    • homeodomain interacting protein kinase 3
    • Homeodomain-interacting protein kinase 3
    • Homolog of protein kinase YAK1
    • PKY
    • RP24 297H17.5
    • YAK1
    see all
  • 機能Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.
  • 組織特異性Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
  • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated, but autophosphorylation is not required for catalytic activity.
    May be sumoylated.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant human HIPK3 protein 画像

  • The Specific activity of ab85601 was determined to be 48 nmol/min/mg.
  • SDS-PAGE showing ab85601 at approximately 49kDa.

Recombinant human HIPK3 protein (ab85601) 使用論文

ab85601 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"