Hexamethylene bis acetamide inducible transcript 1
Hexamethylene bis-acetamide-inducible protein 1
Menage a quatre 1
Menage a quatre protein 1
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
Belongs to the HEXIM family.
The coiled-coil domain mediates oligomerization.
Nucleus. Cytoplasm. Binds alpha-importin and is mostly nuclear.