製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus
  • アミノ酸配列
    • アクセッション番号O15379
    • 生物種Human
    • 分子量83 kDa including tags
    • 領域1 to 428

特性

Our Abpromise guarantee covers the use of ab101663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Specific activity 125 RLU/min/ng.
  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 精製度> 70 % SDS-PAGE.
    ab101663 is >70% pure as assessed by densitometry.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • HD3
    • HDAC 3
    • HDAC3
    • HDAC3_HUMAN
    • Histone deacetylase 3
    • RPD3
    • RPD3 2
    • RPD3-2
    • SMAP45
    see all
  • 機能Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the histone deacetylase family. HD type 1 subfamily.
  • 翻訳後修飾Sumoylated in vitro.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant human HDAC3 protein 画像

  • The specific activity of ab101663 was determined to be 125 RLU/min/ng.
  • The purity of HDAC3 was determined to be >70% as assessed by densitometry.
    The approximate molecular weight is ~83 kDa.

Recombinant human HDAC3 protein (ab101663) 使用論文

ab101663 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"