Recombinant human Haspin protein (ab104026)

製品の概要

  • 製品名Recombinant human Haspin protein
  • タンパク質長Protein fragment

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号Q8TF76
    • 生物種Human
    • 分子量64 kDa including tags
    • 領域470 to 798

特性

Our Abpromise guarantee covers the use of ab104026 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The Specific activity of ab104026 was determined to be 18 nmol/min/mg.
  • アプリケーション

    Functional Studies

    Western blot

  • 精製度> 75 % SDS-PAGE.
    Purity was determined to be >75% by densitometry.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • germ cell associated 2
    • Germ cell-specific gene 2 protein
    • GSG2
    • H-haspin
    • Haploid germ cell-specific nuclear protein kinase
    • HASP_HUMAN
    • Serine/threonine-protein kinase haspin
    see all
  • 機能Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis.
  • 組織特異性Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
  • 配列類似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated on both serine and threonine residues (By similarity). Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant human Haspin protein 画像

  • SDS-PAGE showing ab104026 at approximately 64kDa.
  • The Specific activity of ab104026 was determined to be 18 nmol/min/mg.

Recombinant human Haspin protein (ab104026) 使用論文

ab104026 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"