製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号P25098
    • 生物種Human
    • 分子量102 kDa including tags
    • 領域2 to 689
    • タグGST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The specific activity of ab125620 was determined to be 5.3 nmol/mg/min.
  • アプリケーション

    Western blot

    Functional Studies

    SDS-PAGE

  • 製品の状態Liquid
  • 備考

    ab204876 (Cdc25C peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • ADRBK1
    • Adrenergic beta receptor kinase 1
    • ARBK1_HUMAN
    • BARK
    • BARK1
    • Beta adrenergic receptor kinase 1
    • Beta ARK 1
    • Beta ARK1
    • Beta-adrenergic receptor kinase 1
    • Beta-ARK-1
    • FLJ16718
    • G protein coupled receptor kinase 2
    • G-protein coupled receptor kinase 2
    • GRK2
    see all
  • 機能Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
  • 組織特異性Expressed in peripheral blood leukocytes.
  • 配列類似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 PH domain.
    Contains 1 protein kinase domain.
    Contains 1 RGS domain.
  • Information by UniProt

Recombinant human GRK2 protein 画像

  • The specific activity of ab125620 was determined to be 5.3 nmol/mg/min by Kinase Assay.
  • SDS-PAGE analysis of ab125620.

Recombinant human GRK2 protein (ab125620) 使用論文

ab125620 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"