製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
      Q9UBQ7
    • 生物種
      Human
    • 配列
      MGSSHHHHHH SSGLVPRGSH MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGLLCLLS DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV GYTPDVLTDT TAELAVSLLL TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF INISRGDVVN QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR TRNTMSLLAA NNLLAGLRGE PMPSELKL
    • 分子量
      38 kDa including tags
    • 領域
      1 to 328
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab119159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.
    ab119159 is purified by proprietary chromatographic techniques.
  • 製品の状態
    Liquid
  • 備考
    Please prevent freeze thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 1.17% Sodium chloride, 0.08% DTT, 20% Glycerol

関連情報

  • 別名
    • GLXR
    • glycerate 2 dehydrogenase
    • GLYD
    • Glyoxylate reductase/hydroxypyruvate reductase
    • Grhpr
    • GRHPR_HUMAN
    • OTTHUMP00000021379
    • OTTHUMP00000021380
    • OTTHUMP00000046131
    • PH 2
    • PH2
    • Primary hyperoxaluria type 2
    see all
  • 機能
    Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
  • 組織特異性
    Ubiquitous. Most abundantly expressed in the liver.
  • 関連疾患
    Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.
  • 配列類似性
    Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  • Information by UniProt

参考文献

ab119159 has not yet been referenced specifically in any publications.

ab119159 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

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