Recombinant Human Gremlin 1 protein (ab111462)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号O60565
    • 生物種Human
    • 配列MKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEV LESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCN SFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRV KQCRCISIDLD
    • 分子量18 kDa
    • 領域25 to 184

特性

Our Abpromise guarantee covers the use of ab111462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Constituent: 0.3% Acetic acid

  • 再構成Reconstitute in 50mM acetic acid or sterile water to a concentration of 0.1 mg/ml.

関連情報

  • 別名
    • BMP antagonist 1
    • Cell proliferation inducing gene 2 protein
    • Cell proliferation-inducing gene 2 protein
    • CKTSF1B1
    • colorectal adenoma and carcinoma 1
    • Cysteine knot superfamily 1
    • Cysteine knot superfamily 1, BMP antagonist 1
    • Cysteine knot superfamily BMP antagonist 1
    • DAN domain family member 2
    • DAND2
    • Down regulated in Mos-transformed cells protein
    • Down-regulated in Mos-transformed cells protein
    • DRM
    • grem1
    • GREM1_HUMAN
    • GREMLIN
    • Gremlin 1 homolog, cysteine knot superfamily
    • Gremlin 1 like protein
    • Gremlin 1, cysteine knot superfamily, homolog
    • Gremlin-1
    • Gremlin1
    • IHG-2
    • IHG2
    • Increased in high glucose 2
    • Increased in high glucose protein 2
    • PIG2
    • Proliferation inducing gene 2
    • proliferation inducing gene 2 protein
    see all
  • 機能Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.
  • 組織特異性Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts.
  • 関連疾患Polyposis syndrome, mixed hereditary 1
  • 配列類似性Belongs to the DAN family.
    Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • 細胞内局在Secreted.
  • Information by UniProt

Recombinant Human Gremlin 1 protein 画像

  • SDS-PAGE analysis of recombinant Human Gremlin 1 (ab111462). Samples were loaded in 15% SDS-polyacrylamide gel and stained with Coomassie blue. Lane 1: unreduced Gremlin 1; Lane 2: reduced Gremlin 1.

Recombinant Human Gremlin 1 protein (ab111462) 使用論文

ab111462 has not yet been referenced specifically in any publications.

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The human Gremlin-1 is purified from the inclusion bodies and refolded on the column. So far we do not have verified biological data.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"