製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human

特性

Our Abpromise guarantee covers the use of ab40619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Mass Spectrometry

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Preservatives: 0.017% Imidazole, 0.002% Sodium azide
    Constituents: 0.121% Tris, 0.0174% Sodium chloride

関連情報

  • 別名
    • Abundant SRC homology
    • Adapter protein GRB2
    • ASH
    • Ash protein
    • EGFRBP GRB2
    • Epidermal growth factor receptor binding protein
    • Epidermal growth factor receptor binding protein GRB2
    • GRB 2
    • Grb2
    • GRB2 adapter protein
    • GRB2_HUMAN
    • Grb3 3
    • Growth factor receptor bound protein 2
    • Growth factor receptor bound protein 3
    • Growth factor receptor-bound protein 2
    • HT027
    • MST084
    • MSTP084
    • NCKAP2
    • OTTHUMP00000166096
    • OTTHUMP00000166097
    • OTTHUMP00000166098
    • Protein ash
    • SEM5
    • SH2/SH3 adapter GRB2
    see all
  • 機能
    Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
    Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
  • 配列類似性
    Belongs to the GRB2/sem-5/DRK family.
    Contains 1 SH2 domain.
    Contains 2 SH3 domains.
  • ドメイン
    The SH3 domains mediate interaction with RALGPS1 and SHB.
  • 細胞内局在
    Golgi apparatus.
  • Information by UniProt

画像

  • SDS PAGE analysis of GRB2 Recombinant protein (1µg) stained with Coomassie blue.

参考文献

ab40619 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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