製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P62993
    • 生物種Human
    • 分子量28 kDa
    • 領域1 to 217

特性

Our Abpromise guarantee covers the use of ab116430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF-TOF
  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.40
    Constituent: 99% PBS

関連情報

  • 別名
    • Abundant SRC homology
    • Adapter protein GRB2
    • ASH
    • Ash protein
    • EGFRBP GRB2
    • Epidermal growth factor receptor binding protein
    • Epidermal growth factor receptor binding protein GRB2
    • GRB 2
    • Grb2
    • GRB2 adapter protein
    • GRB2_HUMAN
    • Grb3 3
    • Growth factor receptor bound protein 2
    • Growth factor receptor bound protein 3
    • Growth factor receptor-bound protein 2
    • HT027
    • MST084
    • MSTP084
    • NCKAP2
    • OTTHUMP00000166096
    • OTTHUMP00000166097
    • OTTHUMP00000166098
    • Protein ash
    • SEM5
    • SH2/SH3 adapter GRB2
    see all
  • 機能Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
    Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
  • 配列類似性Belongs to the GRB2/sem-5/DRK family.
    Contains 1 SH2 domain.
    Contains 2 SH3 domains.
  • ドメインThe SH3 domains mediate interaction with RALGPS1 and SHB.
  • 細胞内局在Golgi apparatus.
  • Information by UniProt

Recombinant Human GRB2 protein 画像

  • 10% SDS-PAGE stained with Coomassie Blue (Lane 1), immunobloting with anti-6xHis (Lane 2)

Recombinant Human GRB2 protein (ab116430) 使用論文

ab116430 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab116430.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"