Recombinant Human Granulin protein (ab108947)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P28799
    • 生物種Human
    • 分子量10 kDa including tags
    • 領域364 to 430
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab108947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • エンドトキシン・レベル< 1.000 Eu/µg
  • 精製度> 90 % SDS-PAGE.
    ab108947 is 0.2µm filtered.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2

関連情報

  • 別名
    • Acrogranin
    • CLN11
    • GEP
    • GP88
    • Granulin A
    • Granulin B
    • Granulin C
    • Granulin D
    • Granulin E
    • Granulin epithelin
    • Granulin F
    • Granulin G
    • Granulin-7
    • Granulins
    • GRN
    • GRN_HUMAN
    • PC cell derived growth factor
    • PCDGF
    • PEPI
    • PGRN
    • Proepithelin
    • Progranulin
    see all
  • 機能Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
    Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
  • 組織特異性In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
  • 関連疾患Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.
  • 配列類似性Belongs to the granulin family.
  • 翻訳後修飾Granulins are disulfide bridged.
  • 細胞内局在Secreted.
  • Information by UniProt

Recombinant Human Granulin protein (ab108947) 使用論文

ab108947 has not yet been referenced specifically in any publications.

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