Recombinant human GMCSF + IL3 protein (ab73275)

製品の概要

  • 製品名Recombinant human GMCSF + IL3 protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 分子量30 kDa

特性

Our Abpromise guarantee covers the use of ab73275 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Specific Activity of 5 x 106 IU/mg.
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    This product is purified by proprietary chromatographic techniques. Purity: Greater than 95.0% as determined by: 1. Analysis by RP-HPLC. 2. Analysis by SDS-PAGE.
  • 製品の状態Lyophilised
  • 備考


    Results indicate that this product can stimulate multilineage hematopoiesis in vivo and enhance neutrophil and platelet recovery following chemotherapy and bone marrow transplantation (BMT). These results suggest that this product elicits the biological effects of both its component cytokines and represents a novel means of delivering two independent but interactive cytokines in combination.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1% BSA, 10mM PBS, pH 7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成Reconstitute this product in sterile 18MOhm/cm H2O at not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

関連情報

  • 別名
    • CSF
    • CSF2
    • GM CSF
    • Hematopoietic growth factor
    • IL 3
    • Interleukin 3
    • Interleukin 3 precursor
    • MCGF
    • Multilineage colony stimulating factor
    • P cell stimulating factor
    • Sargramostim
    see all
  • 関連性GMCSF is a cytokine that controls the production, differentiation and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. IL3 is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity and it may be associated with neurologic disorders. Synergism of IL3 together with GMCSF causes a rapid rise in neutrophils due to GMCSF and a slower rise in platelets due to IL3 which has strong stimulated effect on hematopoietic cells.
  • 細胞内局在GMCSF: Secreted. IL3: Secreted.

Recombinant human GMCSF + IL3 protein (ab73275) 使用論文

ab73275 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"