製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P17900
    • 生物種Human
    • 配列MQSLMQAPLLIALGLLLAAPAQAHLKKPSQLSSFSWDNCDEGKDPAVIRS LTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCT DYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKS EFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAASLKGI
    • 分子量47 kDa including tags
    • 領域1 to 193

特性

Our Abpromise guarantee covers the use of ab116790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

    ELISA

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Cerebroside sulfate activator protein
    • ganglioside GM2 activator
    • Ganglioside GM2 activator isoform short
    • Ganglioside GM2 activator precursor
    • GM2 activator
    • GM2 AP
    • GM2 ganglioside activator
    • GM2 ganglioside activator protein
    • GM2-AP
    • GM2A
    • GM2AP
    • OTTHUMP00000160619
    • SAP 3
    • SAP-3
    • SAP3
    • SAP3_HUMAN
    • Shingolipid activator protein 3
    • Sphingolipid activator protein 3
    see all
  • 機能Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
  • 関連疾患Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
  • 翻訳後修飾The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
  • 細胞内局在Lysosome.
  • Information by UniProt

Recombinant Human GM2A protein 画像

  • 12.5% SDS-PAGE showing ab116790 at approximately 47.30kDa.
    Stained with Coomassie Blue.

Recombinant Human GM2A protein (ab116790) 使用論文

ab116790 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"