Recombinant Human Glutaredoxin 5 protein (ab117649)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q86SX6
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MSGSLGRAAA ALLRWGRGAG GGGLWGPGVR AAGSGAGGGG SAEQLDALVK KDKVVVFLKG TPEQPQCGFS NAVVQILRLH GVRDYAAYNV LDDPELRQGI KDYSNWPTIP QVYLNGEFVG GCDILLQMHQ NGDLVEELKK LGIHSALLDE KKDQDSK
    • 分子量19 kDa including tags
    • 領域1 to 157
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab117649 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 85 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 20% Glycerol

関連情報

  • 別名
    • C14orf87
    • Chromosome 14 open reading frame 87
    • FLB4739
    • GLRX 5
    • Glrx5
    • GLRX5_HUMAN
    • Glutaredoxin 5 homolog
    • Glutaredoxin related protein 5
    • Glutaredoxin-related protein 5
    • Glutaredoxin5
    • GRX5
    • MGC14129
    • mitochondrial
    • Monothiol glutaredoxin-5
    • PRO1238
    see all
  • 機能Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
  • 関連疾患Defects in GLRX5 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA) [MIM:205950]. A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus.
  • 配列類似性Belongs to the glutaredoxin family. Monothiol subfamily.
    Contains 1 glutaredoxin domain.
  • 細胞内局在Mitochondrion.
  • Information by UniProt

Recombinant Human Glutaredoxin 5 protein (ab117649) 使用論文

ab117649 has not yet been referenced specifically in any publications.

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